Table 1. Clinicopathological variables related to L1CAM status in curettage specimens for women operated for endometrial cancer.
|
L1CAM |
|||
|---|---|---|---|
| Variable | Low (0–3), n (%) | High (4–9), n (%) | P-value |
| Age (years) | <0.001 | ||
| <66 | 520 (95) | 30 (5) | |
| ⩾66 | 480 (82) | 104 (18) | |
|
Information available preoperatively | |||
| Curettage histologya | <0.001 | ||
| Low risk | 811 (95) | 40 (5) | |
| High risk | 170 (64) | 94 (36) | |
| PR curettage | <0.001 | ||
| Positive | 795 (96) | 36 (4) | |
| Negative | 191 (69) | 88 (31) | |
| ER-α curettage | <0.001 | ||
| Positive | 746 (95) | 43 (5) | |
| Negative | 228 (72) | 89 (28) | |
|
Information available postoperatively | |||
| FIGO-09 stage | <0.001 | ||
| I–II | 872 (91) | 84 (9) | |
| III–IV | 128 (72) | 50 (28) | |
| Histologic type | <0.001 | ||
| Endometrioid | 874 (96) | 36 (4) | |
| Adenosquamous | 10 (91) | 1 (9) | |
| Clear cell | 29 (71) | 12 (29) | |
| Serous papillary | 39 (36) | 70 (64) | |
| Carcinosarcoma | 35 (76) | 11 (24) | |
| Undifferentiated/other | 13 (77) | 4 (23) | |
| Histologic gradeb | <0.001 | ||
| Grade 1/2 | 754 (97) | 21 (3) | |
| Grade 3 | 120 (86) | 19 (14) | |
| Metastatic nodes | <0.001 | ||
| Negative | 657 (92) | 60 (8) | |
| Positive | 77 (72) | 30 (28) | |
| Myometrial infiltration | <0.001 | ||
| <50% | 608 (92) | 51 (8) | |
| ⩾50% | 309 (84) | 60 (16) | |
| Ploidy | <0.001 | ||
| Diploid | 288 (94) | 17 (6) | |
| Aneuploid | 49 (58) | 35 (42) | |
| L1CAM hysterectomy specimen | <0.001 | ||
| Low | 431 (96) | 16 (4) | |
| High | 26 (36) | 46 (64) | |
Abbreviations: ER=oestrogen receptor; FIGO=Federation of Gynaecology and Obstetrics; L1CAM=L1 cell adhesion molecule; PR=progesterone receptor.
Missing information on curettage histology classification for 19 patients, PR status in curettage for 24 patients, ER-α status in curettage for 28 patients, grade for 9 patients, metastatic nodes for 310 patients, myometrial infiltration for 106 patients, ploidy for 745 patients and L1CAM status in hysterectomy specimen for 615 patients.
a
Curettage histological risk classification, low risk (benign, hyperplasia or endometrioid grades 1–2) or high risk (non-endometrioid or endometrioid grade 3).
b
Only endometrioid.