Table 2. Prediction of lymph node metastases based on curettage histology, status of L1CAM and ER/PR in curettage specimen in 763 lymph node sampled endometrial cancer patients.

Variable	Na	Uni-variate OR	95% CI	P	Multivariate OR	95% CI	P	Sensitivity	Specificity	PPV	NPV
Curettage histologyb
Low risk	590	1			1
High risk	173	3.39	2.19–5.23	<0.001	1.94	1.16–3.25	0.011	0.49	0.75	0.22	0.91
L1CAM expression
Low	681	1			1
High	82	4.49	2.69–7.50	<0.001	2.51	1.41–4.64	0.002	0.28	0.92	0.33	0.90
ER/PR expression
Normal	606	1			1
Lossc	157	3.26	2.10–5.07	<0.001	1.91	1.15–3.17	0.013	0.42	0.82	0.26	0.90

Abbreviations: CI=confidence interval; ER=oestrogen receptor; L1CAM=L1 cell adhesion molecule; NPV=negative predictive value; OR=odds ratio; PPV=positive predictive value; PR=progesterone receptor.

^aOnly patients with data available for all variables included in the multivariate logistic regression analysis are included in the univariate analysis (N=763).

^bCurettage histological classification, low risk (benign, hyperplasia or endometrioid grades 1–2) or high risk (non-endometrioid or endometrioid grade 3).

^cPatients with double loss of ER/PR expression.