Table 3. Clinicopathological variables related to sL1CAM status in preoperative blood samples from women treated for endometrial cancer.
|
sL1CAM |
|||
|---|---|---|---|
| Variable | Low, n (%) | High, n (%) | P-value |
| Age (years) | <0.001 | ||
| <66 | 165 (89) | 20 (11) | |
| ⩾66 | 116 (62) | 71 (38) | |
|
Information available preoperatively | |||
| Curettage histologya | <0.001 | ||
| Low risk | 217 (80) | 54 (20) | |
| High risk | 58 (62) | 36 (38) | |
| PR curettage | 0.027 | ||
| Positive | 160 (81) | 37 (20) | |
| Negative | 37 (67) | 18 (33) | |
| ER-α curettage | 0.023 | ||
| Positive | 157 (81) | 37 (19) | |
| Negative | 38 (67) | 19 (33) | |
|
Information available postoperatively | |||
| FIGO-09 stage | <0.001 | ||
| I–II | 252 (80) | 61 (20) | |
| III–IV | 29 (49) | 30 (51) | |
| Histologic type | <0.001 | ||
| Endometrioid | 238 (80) | 61 (20) | |
| Adenosquamous | 4 (100) | 0 (0) | |
| Clear cell | 9 (75) | 3 (25) | |
| Serous papillary | 18 (55) | 15 (45) | |
| Carcinosarcoma | 10 (59) | 7 (41) | |
| Undifferentiated/other | 2 (29) | 5 (71) | |
| Histologic gradeb | 0.95 | ||
| Grade 1/2 | 192 (80) | 48 (20) | |
| Grade 3 | 47 (80) | 12 (20) | |
| Metastatic nodes | 0.003 | ||
| Negative | 225 (83) | 44 (17) | |
| Positive | 22 (63) | 13 (37) | |
| Myometrial infiltration | 0.027 | ||
| <50% | 175 (80) | 42 (20) | |
| ⩾50% | 106 (71) | 44 (29) | |
| Ploidy | 0.15 | ||
| Diploid | 145 (78) | 42 (22) | |
| Aneuploid | 31 (67) | 15 (33) | |
Abbreviations: ER=oestrogen receptor; FIGO=Federation of Gynaecology and Obstetrics; PR=progesterone receptor; sL1CAM= soluble L1 cell adhesion molecule.
Missing information on curettage histology classification for 7 patients, PR status in curettage for 120 patients, ER-α status in curettage for 121 patients, grade for 4 patients, metastatic nodes for 68 patients, myometrial infiltration for 5 patients and ploidy for 139 patients.
a
Curettage histological risk classification, low risk (benign, hyperplasia or endometrioid grades 1–2) or high risk (non-endometrioid or endometrioid grade 3).
b
Only endometrioid.