Table 1. Demographical and clinicopathological characteristics of patients in the Newfoundland Familial Colorectal Cancer Study (NFCCS).
|
Subjects included in this study (N=531) |
Subjects without genotype/disease-outcome information (N=206) | ||||
|---|---|---|---|---|---|
| Characteristic | No. patients (%) | No. deaths (%) | MST (y)a | P log-ranka | No. patients (%) |
| Age at diagnosis (y)b | 60.7±9.2 | 61.3±9.7 | – | – | 62.1±9.6 |
| Sex | |||||
| Female | 201 (37.9) | 56 (27.9) | 6.5 | 83 (40.3) | |
| Male | 330 (62.1) | 127 (38.5) | 6.3 | 0.005 | 123 (59.7) |
| Race | |||||
| White | 439 (96.9) | 133 (30.3) | 6.4 | 27 (93.1) | |
| Other | 14 (3.1) | 8 (57.1) | 4.7 | 0.009 | 2 (6.9) |
| Reported screening procedure | |||||
| Yes | 52 (11.5) | 10 (19.2) | 6.6 | 7 (24.1) | |
| No | 401 (88.5) | 131 (32.7) | 6.4 | 0.059 | 22 (75.9) |
| Tumour location | |||||
| Colon | 341 (66.0) | 110 (32.3) | 6.4 | 124 (72.1) | |
| Rectum | 176 (34.0) | 65 (36.9) | 6.3 | 0.444 | 48 (27.9) |
| Stage at diagnosis | |||||
| I/II | 302 (56.9) | 76 (25.2) | 6.6 | 56 (27.2) | |
| III/IV | 229 (43.1) | 107 (46.7) | 6.0 | <0.001 | 150 (72.8) |
| Surgery | |||||
| Yes | 516 (97.2) | 177 (34.3) | 6.4 | 204 (99.0) | |
| No | 15 (2.8) | 6 (40.0) | 6.8 | 0.790 | 2 (1.0) |
| Chemoradiotherapy | |||||
| Yes | 106 (20.5) | 33 (41.51) | 6.0 | 33 (19.2) | |
| No | 411 (79.5) | 131 (31.87) | 6.4 | 0.036 | 139 (80.8) |
| MSI status | |||||
| MSS/MSI-L | 445 (88.5) | 168 (37.8) | 6.3 | 190 (92.2) | |
| MSI-H | 58 (11.5) | 6 (10.3) | 6.7 | <0.001 | 16 (7.7) |
| BRAF mutation status | |||||
| Wild type | 432 (89.8) | 153 (35.4) | 6.4 | 165 (84.2) | |
| BRAF mutant | 49 (10.2) | 15 (30.6) | 6.3 | 0.370 | 31 (15.8) |
| Dietary vitamin D intake (μg/d)b | 6.3±3.5 | 7.0±4.2 | – | – | 5.5±3.0 |
| Dietary calcium intake (mg/d)b | 965.6±460.7 | 1024.8±504.2 | – | – | 888.3±427.8 |
Abbreviations: BMI=body mass index; MSI=microsatellite instability; MST=median overall survival time; MSI-H=microsatellite instability-high; MSS/MSI-L= microsatellite stable/microsatellite instability-low.
a
The values reported were calculated over the number of subjects with valid information; the numbers of subjects with missing values for each variable are as follows: race (78), reported screening procedure (78), tumour location (14), chemoradiotherapy (14), dietary vitamin D intake (78), dietary calcium intake (78), MSI status (28), BRAF mutation status (50).
b
Continuous variables presented as mean±s.d. (standard deviation).