Table 2. Association between VDR and CASR genes and colorectal cancer overall and disease-free survival (n=531).
|
Overall survival HR (95% CI)a |
Disease-free survival HR (95% CI)a |
|||||
|---|---|---|---|---|---|---|
| All CRC | Colon cancer | Rectum cancer | All CRC | Colon cancer | Rectum cancer | |
|
VDR | ||||||
| PC1 | 0.80 (0.67–0.95) | 0.76 (0.61–0.95) | 0.90 (0.64–1.25) | 0.83 (0.71–0.98) | 0.82 (0.66–1.00) | 0.86 (0.64–1.15) |
| PC2 | 0.99 (0.83–1.17) | 0.85 (0.68–1.07) | 1.41 (1.01–1.98) | 1.00 (0.84–1.19) | 0.84 (0.68–1.04) | 1.78 (1.27–2.50) |
| PC3 | 0.87 (0.74–1.03) | 0.90 (0.73–1.11) | 0.81 (0.58–1.11) | 0.91 (0.77–1.07) | 0.95 (0.77–1.17) | 0.74 (0.55–1.00) |
| PC4 | 1.03 (0.87–1.21) | 1.07 (0.87–1.12) | 0.91 (0.66–1.26) | 1.05 (0.90–1.23) | 1.12 (0.91–1.38) | 0.83 (0.62–1.11) |
| PC5 | 0.90 (0.75–1.08) | 0.89 (0.69–1.14) | 0.97 (0.73–1.30) | 0.91 (0.77–1.08) | 0.92 (0.73–1.15) | 1.02 (0.79–1.32) |
| PC6 | 0.96 (0.81–1.13) | 1.01 (0.82–1.25) | 0.84 (0.63–1.12) | 1.07 (0.91–1.26) | 1.06 (0.85–1.30) | 1.10 (0.83–1.45) |
| PC7 | 1.05 (0.88–1.24) | 1.10 (0.87–1.38) | 1.11 (0.83–1.47) | 1.09 (0.93–1.28) | 1.10 (0.89–1.37) | 1.09 (0.85–1.39) |
| PC8 | 0.98 (0.83–1.17) | 0.90 (0.73–1.11) | 1.26 (0.90–1.77) | 1.02 (0.86–1.20) | 0.87 (0.71–1.07) | 1.60 (1.17–2.17) |
| Global Pb | 0.201 | 0.193 | 0.206 | 0.320 | 0.241 | 0.037 |
|
CASR | ||||||
| PC1 | 1.09 (0.91–1.29) | 1.04 (0.84–1.30) | 1.25 (0.90–1.74) | 1.10 (0.93–1.29) | 1.02 (0.83–1.26) | 1.29 (0.95–1.75) |
| PC2 | 0.94 (0.80–1.10) | 0.84 (0.68–1.04) | 1.20 (0.90–1.61) | 0.96 (0.83–1.12) | 0.92 (0.76–1.12) | 1.15 (0.89–1.49) |
| PC3 | 1.12 (0.95–1.31) | 1.23 (1.01–1.50) | 1.07 (0.81–1.41) | 1.13 (0.98–1.30) | 1.15 (0.95–1.39) | 1.15 (0.91–1.44) |
| PC4 | 0.95 (0.80–1.13) | 1.02 (0.83–1.26) | 0.91 (0.66–1.25) | 1.03 (0.89–1.20) | 1.07 (0.90–1.28) | 1.03 (0.79–1.34) |
| PC5 | 0.94 (0.78–1.13) | 0.85 (0.68–1.07) | 1.19 (0.81–1.76) | 0.94 (0.80–1.11) | 0.87 (0.71–1.06) | 1.15 (0.82–1.60) |
| PC6 | 1.10 (0.91–1.32) | 1.26 (0.98–1.61) | 0.82 (0.60–1.12) | 1.12 (0.95–1.33) | 1.27 (1.01–1.59) | 0.89 (0.69–1.15) |
| PC7 | 0.80 (0.65–0.98) | 0.72 (0.55–0.94) | 0.95 (0.68–1.33) | 0.88 (0.73–1.05) | 0.81 (0.64–1.03) | 0.96 (0.71–1.29) |
| Global Pb | 0.209 | 0.014 | 0.486 | 0.258 | 0.075 | 0.492 |
Abbreviations: CRC=colorectal cancer; HR=hazard ratio; PC=principal component.
a
Cox proportional hazard model adjusted for age at diagnosis, sex, race, stage at diagnosis, reported screening procedure, marital status, MSI status, and BRAF mutation status where applicable; subjects with missing information on tumour location (n=14) were excluded from the stratified analysis.
b
Global P for association is from a likelihood ratio test with degrees of freedom equal to the number of PCs.