Skip to main content
. 2017 Aug 15;117(6):876–883. doi: 10.1038/bjc.2017.258

Figure 1.

Figure 1

Comparison of HPV16 status by E7 mRNA, p16 staining and HPV16-detect (NGS) assay in tissue and plasma. (A) There was 100% agreement between the HPV16 status assigned by the ‘gold standard’ E7 mRNA expression and HPV16-detect. (B) Test cohort: HPV16-detect assay demonstrated 100% sensitivity and 92.9% specificity in detecting HPV DNA in plasma compared to tissue. (C) Validation cohort: HPV16-detect assay demonstrated 90% sensitivity and 100% specificity in assigning HPV status in plasma compared to p16 staining in tissue. NPV=negative predictive value; PPV=positive predictive value.