Figure 2.

HPV DNA tracking in treatment responsive HPV+ patients using the HPV16-detect assay. HPV DNA levels decreased below threshold at 12-weeks post-treatment in patients receiving C-CRT (n=19, A) and in patients who received induction chemotherapy (IC) and CRT (n=7, B). Red plots in (A) highlight the three patients in (C–E). Residual disease was evident in three patients by ¹⁸F-FDG PET-CT (C–E), with negative biopsies and below threshold levels of HPV DNA in the plasma taken at the time of biopsies (PA). PA=post-assessment; post-IC=post-induction chemotherapy. A full colour version of this figure is available at the British Journal of Cancer journal online.