Table I.
Clinical characteristics of the patients (n=50).
| Characteristics | Patients (n) |
|---|---|
| Age, years | |
| <65 | 27 |
| ≥65 | 23 |
| Sex | |
| Male | 25 |
| Female | 25 |
| Performance status | |
| 0–2 | 40 |
| 3–4 | 10 |
| Genotype: COMT 472G→A (rs4680; p.Val158Met) | |
| G/G | 29 |
| A/G | 19 |
| A/A | 2 |
| Tumor type | |
| Lung | 19 |
| Breast | 9 |
| Colorectal | 5 |
| Head and neck | 4 |
| Gastric | 3 |
| Unknown primary | 3 |
| Gallbladder | 2 |
| Pancreas | 2 |
| Others | 3 |
| Required dose of morphine on day 1 (mg) | |
| 20 | 2 |
| 30 | 43 |
| 60 | 5 |
| Required dose of morphine on day 8 (mg) | |
| As required | 8 |
| 20 | 3 |
| 30 | 30 |
| 60 | 6 |
| 90 | 1 |
| N.E. | 2 |
| Day 1 (pre-treatment) pain NRS, mean (SD) | |
| All patients | 6.88 (2.43) |
| G/G | 7.07 (2.25) |
| Non-G/G (A/A and A/G) | 6.62 (2.69) |
| Day 1 (post-treatment) pain NRS, mean (SD) | |
| All patients | 2.46 (1.46) |
| G/G | 2.38 (1.45) |
| Non-G/G (A/A and A/G) | 2.57 (1.50) |
| Day 8 pain NRS, mean (SD) | |
| All patients | 3.60 (2.73) |
| G/G | 3.17 (2.63) |
| Non-G/G (A/A and A/G) | 4.19 (2.80) |
COMT, catechol-O-methyltransferase; N.E, not evaluated; NRS, numerical rating scale; SD, standard deviation.