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. 2017 Jun 9;4(2):38. doi: 10.3390/medicines4020038

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of treatment with essential oil from Artemisia absinthium L. collected in Havana, Cuba, in comparison with the oil formulated in nanocochletaes. BALB/c mice were infected with L. amazonensis and 30 days post-infection the treatment was started with four doses by intralesional route at 30 mg/kg every four days. The results are expressed as mean of lesion size in infected area ± standard deviation. EO-Aa: essential oil from A. absinthium; EO-Aa-NC: essential oil from A. absinthium formulated in nanocochleates; NC: empty nanocochleates; GTM: Glucantime^® used as a reference drug. *: displays statistical differences (p < 0.05) compared to control untreated animals. **: displays statistical differences (p < 0.05) compared to animals treated with EO-Aa. a: a positive number represents an increase of body weight, while a negative number indicated decrease of body weight. EO-Aa: essential oil from A. absinthium. EO-Aa-NC: essential oil from A. absinthium formulated in nanocochleates. NC: empty nanocochleates. GTM: Glucantime^® used as reference drug.