Figure 5. Evolutionary comparison GDF9, BMP15, and BMPR1B protein residues at their variant sites in U.S. sheep.

Aligned protein sequences from a representative subset of 29 vertebrate species were compared. Abbreviations and symbols are as follows: TMRCA, estimated time to most recent common ancestor in millions of years ⁴⁸; letters, IUPAC/IUBMB codes for amino acids; dot, amino acid residues identical to those in sheep “variant 1”; triangle, net deletion of one leucine residue in BMP15 positions 10 and 11 where two leucine residues are commonly present; ni, a fourth protein variant was not identified for BMPR1B; nr, not in refseq_protein database and thus residues were determined by analyzing WGS data; dash, not enough sequence similarity for comparison or missing polypeptide region; nm, did not match a refseq_protein in the database for that species.