Table 4. Frequency estimates of GDF9, BMP15, and BMPR1B protein variants by breed group.
| Protein variant frequency a | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GDF9 | BMP15 | BMPR1B | ||||||||||||
| 1 | 2 | 3 | 4 b | 1 | 2 | 3 c | 4 c | 1 | 2 d | 3 d | ||||
| Breed group | No. | (Ref.) | (I332) | (H87,
K241) |
(M371) | (Ref.) | (ΔL) | (P252) | (Q67) | (Ref.) | (I64) | (N345) | ||
| Dorper | 6 | 0.33 | 0.67 | - e | - | 0.17 | 0.50 | 0.33 | - | 1.00 | - | - | ||
| Dorper, white | 4 | 0.75 | 0.25 | - | - | - | - | 1.00 | - | 1.00 | - | - | ||
| Dorset | 11 | 0.64 | 0.36 | - | - | 0.82 | 0.09 | - | 0.09 | 1.00 | - | - | ||
| Finn | 10 | 0.55 | 0.20 | - | 0.25 | 0.70 | 0.30 | - | - | 0.95 | - | 0.05 | ||
| Katahdin | 8 | 0.75 | 0.25 | - | - | 1.00 | - | - | - | 0.81 | 0.19 | - | ||
| Navajo-Churro | 1 | 1.00 | - | - | - | 1.00 | - | - | - | 1.00 | - | - | ||
| Rambouillet | 10 | 0.85 | 0.15 | - | - | 0.20 | 0.80 | - | - | 1.00 | - | - | ||
| Romanov | 10 | 0.30 | 0.60 | 0.10 | - | 0.30 | 0.70 | - | - | 0.80 | - | 0.20 | ||
| Suffolk | 9 | 0.94 | 0.06 | - | - | 1.00 | - | - | - | 1.00 | - | - | ||
| Texel | 10 | 0.70 | 0.10 | 0.20 | - | 0.90 | 0.10 | - | - | 1.00 | - | - | ||
| Composite | 17 | 0.88 | 0.09 | 0.03 | - | 0.82 | 0.06 | 0.12 | - | 0.94 | 0.06 | - | ||
aThe variants correspond to those shown in Figure 4. The distinctive missense variant or reference isoform is indicated in parentheses.
bGDF9 protein “variant 4" contains the M371 amino acid previously associated with litter size in Finnish landrace sheep 11, 26, 37.
cBMP15 protein “variants 3 and 4" contain the previously unreported P252, and Q67 residues, respectively.
dBMPR1B protein “variants 2 and 3” contain the previously unreported I64 and N345 missense variants, respectively.
eHyphen indicates the variant was not detected in that group.