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. 2017 Sep 7;50:27. doi: 10.1186/s40659-017-0133-8

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Effect of miR-22 overexpression on tumorigenesis and radiosensitivity of breast cancer cells. MCF-7 and MDA-MB-231 cells were transfected with miR-22 or miR-NC and cultured for 48 h. Cell viability in transfected MCF-7 (a) and MDA-MB-231 (b) cells were examined by CCK-8 assay. Apoptosis of transfected MCF-7 (c) and MDA-MB-231 (d) cells was assessed by flow cytometry analysis. Colony formation assay was performed to detect survival fraction in transfected MCF-7 (e) and MDA-MB-231 (f) cells with indicated doses of irradiation (0, 2, 4, 6, or 8 Gy). γ-H2AX foci formation assay was carried out to detect the number of γ-H2AX foci in transfected MCF-7 (g) and MDA-MB-231 (h) cells with 6 Gy radiation. *P < 0.05