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. 2017 Sep 7;50:27. doi: 10.1186/s40659-017-0133-8

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — miR-22 suppressed tumorigenesis and improved radiosensitivity of breast cancer cells by targeting sirt1. MCF-7 and MDA-MB-231 cells were transfected with miR-22, miR-NC or combined miR-22 and pcDNA-sirt1 and further experiment analyses were carried out 48 h post-transfection. Cell viability of transfected MCF-7 (a) and MDA-MB-231 (b) cells were assessed by CCK-8 assay. Flow cytometry analysis was performed to determine apoptosis in transfected MCF-7 (c) and MDA-MB-231 (d) cells. Colony formation assay was carried out to calculate survival fractions in transfected MCF-7 (e) and MDA-MB-231 (f) cells after treatment with different single doses of irradiation (0, 2, 4, 6, or 8 Gy). *P < 0.05