Table 1.
Clinical features of patients who underwent hematopoietic stem cell transplantation complicated with severe late-onset idiopathic pneumonia syndrome
| Case | Sex | Primary disease | Age at HSCT | Type of donor/Stem cells | HLA compatibility | Conditioning regimen | GVHD prophylaxis | Grades of acute GVHD | Type of chronic GVHD [1] | Organs of chronic GVHD | Months from HSCT to Dx of chronic GVHD | Smoking history | History of Infections | Out-come |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | ALL | 48 | UR/BM | DR serological 1 locus mismatch |
TBI (12 Gy) CY |
TAC + MTX | II | Extensive | M, E, L | 7.0 | – | CMV Retinitis Adenovirus cystitis Bacterial pneumonia |
Dead |
| 2 | F | MDS | 43 | UR/BM | complete match | TBI (12 Gy) CyA |
TAC + MTX | II | Extensive | S, M, E, L | 9.4 | – | Bacterial pneumonia Influenza virus bronchitis | Alive |
| 3 | M | AML | 12 | UR/BM | complete match | TBI (12 Gy) CyA, CY |
TAC + MTX | II | Extensive | S, M, E, L | 4.4 | – | MRSA pleuritis | Dead |
| 4 | F | ALL | 53 | UR/BM | complete match | TBI (12 Gy) CyA, CY |
TAC + MTX | I | Extensive | S, M | 3.7 | – | CMV enterocolitis | Alive |
| 5 | F | CML | 35 | UR/BM | DRB1 1 allele mismatch | TBI (12 Gy) CyA, CY |
TAC + MTX | III | Extensive | S, M, E, G | 4.1 | – | – | Dead |
| 6 | F | ALL | 32 | R/BM | complete match | BU, CY | CyA + MTX | 0 | Extensive | E, L | 4.8 | – | Aspergillus pneumonia Listeria bacteremia |
Dead |
| 7 | M | MM | 39 | UR/BM | DRB1 1 allele mismatch | Flu, L-PAM | TAC + MTX | I | Extensive | S, E | 2.2 | – | Bacterial pneumonia HHV6 encephalomyelitis | Dead |
| 8 | F | ALL | 49 | R/BM | complete match | TBI (12 Gy) CyA, CY |
CyA + MTX | III | Extensive | M,G | 4.9 | – | Pseudomonas pneumonia CMV infection (unknown focus) | Dead |
| 9 | M | AML | 31 | UR/BM | DRB1 1 allele mismatch | TBI (12 Gy) CyA |
TAC + MTX | II | Extensive | S, M, E | 4.0 | – | Bacterial pneumonia, CMV infection (unknown focus) | Alive |
| 10 | M | AML | 44 | UR/BM | A 1 allele mismatch | TBI (12 Gy) CyA |
TAC + MTX | I | Extensive | S, M, E, L | 4.5 | + | Cholecystitis CMV infection (unknown focus) |
Dead |
| 11 | F | CML | 33 | UR/ BM | complete match | TBI (12 Gy) CyA |
TAC + MTX | I | Extensive | S, M, E, L | 3.2 | – | Bacterial pneumonia | Alive |
| 12 | M | ALL | 43 | UR/BM | complete match | TBI (12 Gy) CyA, CY |
TAC + MTX | III | Extensive | S, M, E, L | 46.4 | – | – | Dead |
M male, F female, ALL acute lymphocytic leukemia, MDS myelodysplastic syndrome; AML acute myeloid leukemia, CML chronic myelogenous leukemia, MM multiple myeloma, HSCT hematopoietic stem cell transplantation, UR unrelated, R related, BM bone marrow cells, HLA human leukocyte antigen, TBI total body irradiation, CY cyclophosphamide, CyA cyclosporine A, BU busulphan, Flu fludarabine, L-PAM melphalan, GVHD graft-versus-host disease, TAC tacrolimus, MTX methotrexate, M mouth, E eye, L liver, S skin, G gastrointestinal tract, Dx diagnosis, HHV6 human herpesvirus 6