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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Int J Med Inform. 2017 Jul 24;106:48–56. doi: 10.1016/j.ijmedinf.2017.07.002

Table 9.

Datasets, data analysis methods, and key findings for selected studies in research foci 7 – understanding the relationship between cognition and AD.

Study Datasets Primary data analysis methods Key findings
Vemuri et al. (68) Clinical and cognitive assessments, CSF, MRI (98 AD, 192 MCI, 109 HC from ADNI) Correlation analysis Cognitive reserve and biomarkers of AD pathology are independent predictors of cognitive performance
Vemuri et al. (69) Imaging biomarkers, cognitive reserve variables, global cognition measure (393 healthy subjects with one clinical follow-up from MCSA) Association analysis, linear mixed model Cognitive reserve offset the deleterious effect of pathologies of the cognitive trajectories
Amieva et al (70) Neuropsychological evaluation from 442 AD subjects with 20 years follow-up (171 low education, 271 high education) from PAQUID cohort Linear mixed model Cognitive decline occurred up to 16 years and 7 years before AD for high- educated and low-educated individuals, respectively