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PTPRD gene mutations identified in HNSCC.
| Mutation | Location on gene | |
|---|---|---|
| D50E | Immunoglobulin (Ig) | Extracellular domain |
| T111N | Ig | |
| Q196H | Second Ig-like domain of the receptor protein tyrosine phosphatase (IG2) | |
| K204E | IG2 | |
| P249L | IG2 | |
| L308P | IG2 | |
| S384R | Fibronectin type 3 domain (FN3) | |
| L503I | FN3 | |
| E529Q | FN3 | |
| T820P | FN3 | |
| L1014M | FN3 | |
| L1036P | FN3 | |
| T1100M | Transmembrane region | |
| L1147F | Transmembrane region | |
| S1247T | Transmembrane region | |
| V1270L | Transmembrane region | |
| P1311T | Transmembrane region | |
| K1502M | Catalytic domain |
