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. Author manuscript; available in PMC: 2017 Sep 8.
Published in final edited form as: Oral Dis. 2016 Apr;22(Suppl 1):181–192. doi: 10.1111/odi.12418

Table 4.

Histological antibodies and molecular targets and bodily fluids useful for the diagnosis of viral co-infections

Histological Assays Molecular Assays
Virus Immunohistochemical Markers Target Specimen
HSV-1 anti-HSV-1/2 pAb (CP108) US5 Region WMF, Plasma
HSV-2 anti-HSV-1/2 pAb (CP108) Glycoprotein D (US6) Plasma
VZV anti-VZV gE mAb (ORF68, C90.2.8) MBP (ORF29) / gpI (ORF67) PBMC, Plasma
EBV EBV-EBER and EBV-LMP EBNA-1 / BALF5 WMF, PBMC
HCMV anti-HCMV clone DDG9 + CCH2 mAb UL83 gene / MIE region WMF, PBMC, Plasma
HHV-8 NCL-HHV8-LNA (13B10) ORF26 & ORF73 WMF, PBMC, Plasma
HPV P16 IHC (p16INK4A); HPV16 IHC Latent Protein 1 WMF, PBMC*

PBMC = peripheral blood mononuclear cells

*

HPV is detectable in PBMC’s but is controversial.