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. 2017 May 8;4(2):42. doi: 10.3390/bioengineering4020042

Figure 7.

Figure 7

Antibody-dependent cellular cytotoxicity mediated by hTM, CM, hPM and hKM IgA2 antibodies against SK-BR-3, ZR-75-1 or Panc-1 target cells. Granulocytes isolated from peripheral blood were used as effector cells. Mean values (±SEM) of triplicates are shown. hTM (a) and CM IgA2 (b) mediated specific lysis of SK-BR-3 (Her2 +++, EGFR +) target cells. The irrelevant matched isotype control did not mediate lysis of SK-BR-3 target cells. hPM (c), and hKM IgA2 (d) mediated specific lysis of ZR-75-1 (TA-MUC1 +++) and Panc-1 (TF +) target cells, respectively. Antigen binding sites were determined using IgG antibodies and are indicated in brackets; antigen binding sites: +, 1 × 104 to 1 × 105; ++, 1 × 105 to 5 × 105; +++, >5 × 105. One representative out of at least two independent experiments is shown.