Table 2.
MRI measures of the lung area, and the diaphragm and chest wall motion in individuals with Duchenne muscular dystrophy (DMD) and healthy volunteer boys (controls)
| DMD (n = 11), median (IQR) | Controls (n = 15), median (IQR) | P‐value (Wilcoxon rank sum) | |
|---|---|---|---|
| Lung area Inspa (cm2) | 127.3 (101.7–135.1) | 148.2 (130.4–156.2) | 0.02 |
| Lung area Expb (cm2) | 74.6 (72.5–91.9) | 99.9 (90.0–107.3) | <0.01 |
| Lung area deltac (cm2) | 42.4 (20.7–52.3) | 42.3 (35.7–48.0) | 0.68 |
| ANT distance Insp (cm) | 12.6 (11.8–13.8) | 15.3 (14.5–16.2) | <0.01 |
| ANT distance Exp (cm) | 10.7 (9.7–12.0) | 13.2 (11.9–14.5) | <0.01 |
| ANT distance delta (cm) | 2.1 (1.2–2.4) | 2.3 (2.1–2.6) | 0.18 |
| POST distance Insp (cm) | 15.8 (12.5–16.2) | 17.4 (16.7–18.5) | <0.01 |
| POST distance Exp (cm) | 11.3 (10.3–12.0) | 13.7 (12.7–14.3) | <0.01 |
| POST distance delta (cm) | 3.9 (1.7–4.7) | 3.8 (3.3–4.5) | 0.88 |
| CNT distance Insp (cm) | 12.6 (10.6–13.5) | 14.4 (13.1–15.1) | 0.02 |
| CNT distance Exp (cm) | 8.8 (8.5–10.3) | 11.3 (10.3–11.9) | <0.01 |
| CNT distance delta (cm) | 3.5 (1.9–3.7) | 2.9 (2.6–3.2) | 0.55 |
| Diaphragm lengthd Insp (cm) | 14.2 (13.7–14.9) | 14.0 (13.1–15.0) | 0.65 |
| Diaphragm lengthd Exp (cm) | 21.6 (20.1–24.7) | 21.8 (19.9–22.8) | 0.75 |
| Diaphragm lengthd Insp/Exp (%) | 68.3 (62.7–69.9) | 65.3 (63.2–70.7) | 0.92 |
| Diaphragm motion (cm2) | 29.1 (14.8–34.4) | 27.1 (20.1–30.5) | 0.84 |
| Chest wall motion (cm2) | 95.8 (82.3–104.1) | 115.4 (101.6–125.0) | <0.01 |
a
Insp = Inspiration.
b
Exp = Expiration.
c
Delta = change in the measure between maximum inspiration frame and maximum expiration frame in each breath cycle.
d
DMD participants n = 9, controls = 12.