Table 1.
Baseline Characteristics of Participants by Fifth of Serum Uric Acid
| Serum Uric Acid Level (μmol/L)
|
|||||||
|---|---|---|---|---|---|---|---|
| Overall (n = 15,083) |
37.88 – 218.55 (n = 3,017) |
218.56 – 258.97 (n = 3,017) |
259.01 – 296.58 (n = 3,016) |
296.59 – 344.41 (n = 3,017) |
344.43 – 782.75 (n = 3,016) |
P-trend* | |
| Serum Uric Acid, μmol/L (SD)† | 283.5 (75.4) | 186.9 (25.5) | 239.0 (11.5) | 277.3 (10.8) | 318.9 (13.6) | 395.4 (47.4) | – |
| Age, yr (SD) | 48.7 (9.3) | 46.6 (8.7) | 48.5 (9.1) | 49.2 (9.3) | 49.5 (9.6) | 49.5 (9.6) | <0.001 |
| Male, No. (%) | 7,559 (50.1) | 299 (9.9) | 890 (29.5) | 1,676 (55.6) | 2,172 (72.0) | 2,522 (83.6) | <0.001 |
| Body Mass Index, kg/m2 (SD) | 25.8 (4.2) | 24.0 (3.7) | 25.1 (3.9) | 25.8 (3.9) | 26.6 (4.2) | 27.7 (4.5) | <0.001 |
| Total Cholesterol, mmol/L (SD)‡ | 6.3 (1.2) | 6.1 (1.2) | 6.3 (1.3) | 6.3 (1.3) | 6.3 (1.2) | 6.5 (1.2) | <0.001 |
| HDLc, mmol/L (SD)‡ | 1.5 (0.4) | 1.6 (0.4) | 1.6 (0.4) | 1.5 (0.4) | 1.4 (0.4) | 1.3 (0.4) | <0.001 |
| Systolic Blood Pressure, mmHg (SD) | 131.8 (20.3) | 126.8 (19.3) | 129.8 (20.4) | 132.3 (19.9) | 133.8 (20.5) | 136.4 (20.1) | <0.001 |
| Diastolic Blood Pressure, mmHg (SD) | 81.1 (12.0) | 77.6 (11.3) | 79.5 (11.7) | 81.1 (11.7) | 82.6 (12.0) | 84.7 (12.1) | <0.001 |
| Blood Pressure-Lowering Medication Use, No. (%) | 1,849 (12.3) | 146 (4.8) | 271 (9.0) | 322 (10.7) | 423 (14.0) | 687 (22.8) | <0.001 |
| Cigarette Smokers, No. (%) | 5,778 (38.3) | 1,262 (41.8) | 1,238 (41.0) | 1,221 (40.5) | 1,127 (37.4) | 930 (30.8) | <0.001 |
| Cigarettes per Day among Smokers (SD) | 18.5 (9.1) | 17.5 (8.0) | 18.1 (8.5) | 18.9 (9.2) | 19.0 (9.5) | 19.4 (10.4) | 0.19 |
| Diabetes, No. (%) | 246 (1.6) | 73 (2.4) | 40 (1.3) | 43 (1.4) | 44 (1.5) | 46 (1.5) | <0.001 |
| Alcohol Use (g/d) | 14.1 (20.6) | 6.5 (9.9) | 9.7 (15.4) | 12.8 (17.6) | 17.4 (22.1) | 24.3 (28.3) | <0.001 |
| Scottish Index of Multiple Deprivation | 28.9 (22.2) | 28.5 (22.0) | 28.4 (21.9) | 29.0 (22.3) | 29.2 (22.6) | 29.2 (22.2) | 0.003 |
*
P-trend evaluated with linear or logistic regression using the median uric acid value for each fifth as an ordinal variable adjusted for age and sex.
†
The median serum uric acid was 276.72 (interquartile range: 229.27, 330.29).
‡
Convert cholesterol to mg/dL by dividing by 0.0259