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. Author manuscript; available in PMC: 2018 Jul 13.
Published in final edited form as: J Med Chem. 2017 Jun 22;60(13):5507–5520. doi: 10.1021/acs.jmedchem.7b00189

Table 2.

SAR of the Acetylphenyl Moiety

graphic file with name nihms902393u3.jpg
MIC50 (μM)
Compound R BioA-UE BioA-OE WT-biotin WT+biotin
12 graphic file with name nihms902393t16.jpg 0.5 7.5 5.1 30.1
21 graphic file with name nihms902393t17.jpg >50 >50 >50 >50
22 graphic file with name nihms902393t18.jpg 24.4 >50 22.0 >50
23 graphic file with name nihms902393t19.jpg >50 >50 >50 >50
24 graphic file with name nihms902393t20.jpg >50 >50 >50 >50
25 graphic file with name nihms902393t21.jpg 0.4 38.9 6.7 >50
26 graphic file with name nihms902393t22.jpg 0.3 8.1 4.4 47.0
27 graphic file with name nihms902393t23.jpg 1.8 >50 35.0 >50
28 graphic file with name nihms902393t24.jpg 1.2 >50 15.2 >50
29 graphic file with name nihms902393t25.jpg 12.8 >50 40.8 48.0
30 graphic file with name nihms902393t26.jpg 26.6 >50 >50 47.1
31 graphic file with name nihms902393t27.jpg >50 >50 >50 >50
32 graphic file with name nihms902393t28.jpg 44.8 45.9 18.5 22.7
33 graphic file with name nihms902393t29.jpg 4.7 20.9 15.4 11.8
34 graphic file with name nihms902393t30.jpg 1.1 7.6 9.9 19.0
35 graphic file with name nihms902393t31.jpg 15.1 >50 20.4 39.1