TABLE 2.
Live birth rates by cycle- and transfer-level characteristics among autologous and donor, cryopreserved and fresh oocyte cycles started in 2013.
| Characteristic | Autologous cycles | Donor cycles | ||||||
|---|---|---|---|---|---|---|---|---|
| Cryopreserved oocytea cycles | Fresh oocyte cycles | Cryopreserved oocytea cycles | Fresh oocyte cycles | |||||
| Live birth, n (%) | P value | Live birth, n (%) | P value | Live birth, n (%) | P value | Live birth, n (%) | P value | |
| All cycles | 100 (23.7) | 27,266 (29.3) | 955 (43.0) | 4,789 (49.4) | ||||
| Patient age at cycle start (y) | .11 | <.001 | .11 | .005 | ||||
| <30 | 13 (27.7) | 4,621 (42.5) | 8 (29.6) | 135 (47.9) | ||||
| 30–34 | 27 (25.7) | 11,314 (38.9) | 65 (41.9) | 465 (55.0) | ||||
| 35–39 | 32 (28.8) | 9,069 (28.3) | 196 (47.1) | 1,004 (50.9) | ||||
| ≥40 | 28 (17.6) | 2,262 (10.7) | 686 (42.2) | 3,184 (48.3) | ||||
| No. of prior pregnanciesb | .48 | <.001 | .61 | .87 | ||||
| 0 | 52 (25.2) | 13,320 (30.8) | 394 (43.9) | 1,897 (49.3) | ||||
| ≥1 | 48 (22.3) | 13,919 (27.9) | 557 (42.4) | 2,871 (49.5) | ||||
| No. of prior birthsb | .13 | .01 | .45 | .27 | ||||
| 0 | 84 (25.1) | 19,889 (29.6) | 684 (42.5) | 3,460 (49.0) | ||||
| ≥1 | 16 (18.4) | 7,336 (28.5) | 265 (44.3) | 1,306 (50.5) | ||||
| No. of prior ART cyclesb | .33 | <.001 | .03 | .99 | ||||
| 0 | 18 (29.0) | 17,709 (33.0) | 467 (45.5) | 2,023 (49.4) | ||||
| ≥1 | 82 (22.8) | 9,509 (24.2) | 488 (40.8) | 2,761 (49.4) | ||||
| Reason for ART | ||||||||
| Diminished ovarian reserve | 19 (18.1) | .16 | 4,762 (17.4) | <.001 | 774 (43.0) | .89 | 3,627 (49.2) | .66 |
| No diminished ovarian reserve | 81 (25.6) | 22,504 (34.2) | 181 (42.7) | 1,162 (50.1) | ||||
| Endometriosis | 7 (22.6) | .88 | 2,775 (31.4) | <.001 | 46 (42.2) | .88 | 255 (48.9) | .84 |
| No endometriosis | 93 (23.8) | 24,491 (29.0) | 909 (43.0) | 4,534 (49.4) | ||||
| Ovulation disorder | 16 (30.2) | .20 | 4,610 (37.4) | <.001 | 32 (53.3) | .05 | 158 (57.0) | .01 |
| No ovulation disorder | 84 (22.8) | 22,656 (28.0) | 923 (42.7) | 4,631 (49.2) | ||||
| Tubal factor | —d | .05 | 3,793 (28.3) | .04 | 59 (39.6) | .37 | 286 (42.2) | .01 |
| No tubal factor | 96 (24.9) | 23,473 (29.4) | 896 (43.2) | 4,503 (50.0) | ||||
| Uterine factor | SUPP | .06 | 1,046 (23.1) | <.001 | 55 (45.8) | .63 | 279 (46.1) | .15 |
| No uterine factor | 98 (24.4) | 26,220 (29.6) | 900 (42.8) | 4,510 (49.6) | ||||
| Male factor | 49 (29.7) | .07 | 10,850 (33.4) | <.001 | 143 (44.7) | .52 | 802 (50.8) | .33 |
| No male factor | 51 (19.8) | 16,416 (27.1) | 812 (42.7) | 3,987 (49.1) | ||||
| Other | 23 (19.2) | .20 | 2,861 (23.9) | <.001 | 149 (44.7) | .48 | 930 (50.4) | .57 |
| No other | 77 (25.5) | 24,405 (30.0) | 806 (42.6) | 3,859 (49.2) | ||||
| Unexplained | —d | .26 | 4,621 (33.6) | <.001 | 52 (39.1) | .44 | 194 (45.5) | .47 |
| No unexplained | 96 (24.2) | 22,645 (28.5) | 903 (43.2) | 4,595 (49.6) | ||||
| Clinic size | .86 | .13 | .20 | .34 | ||||
| 0–99 cycles | —d | 1,129 (26.7) | SUPP | 138 (42.2) | ||||
| 100–199 cycles | —d | 2,946 (30.5) | 21 (33.9) | 431 (48.9) | ||||
| 200–499 cycles | 14 (26.9) | 6,357 (31.0) | 80 (38.1) | 1,055 (49.5) | ||||
| ≥500 cycles | 80 (22.9) | 16,834 (28.5) | 852 (43.9) | 3,165 (49.9) | ||||
| Transfers onlyc | 100 (30.6) | 27,265 (37.4) | 955 (47.0) | 4,788 (55.9) | ||||
| Age of woman providing oocyte at time of retrieval (y)b | .33 | <.001 | .93 | .02 | ||||
| <30 | 13 (30.2) | 4,549 (50.1) | 687 (48.6) | 3,654 (56.3) | ||||
| 30–34 | 30 (34.9) | 11,320 (46.4) | 91 (47.2) | 625 (56.4) | ||||
| ≥35 | 30 (25.2) | 11,396 (28.8) | —d (50.0) | 68 (43.0) | ||||
| No. of oocytes retrievedc | .18 | <.001 | — | <.001 | ||||
| 0–10 | 14 (23.3) | 10,257 (29.7) | —e | 487 (47.7) | ||||
| ≥11 | 48 (32.7) | 17,008 (44.3) | —e | 4,301 (57.0) | ||||
| Intracytoplasmic sperm injection | .92 | .46 | .38 | .08 | ||||
| Yes | 98 (30.5) | 20,745 (37.2) | 951 (47.0) | 3,768 (55.1) | ||||
| No | —d | 6,515 (37.8) | —d | 1,018 (59.0) | ||||
| No. of embryos cryopreservedb | .001 | <.001 | <.001 | <.001 | ||||
| 0 | 61 (24.6) | 10,878 (27.4) | 384 (38.9) | 786 (44.6) | ||||
| ≥1 | 39 (50.6) | 16,295 (49.5) | 571 (54.6) | 3,965 (58.8) | ||||
| Assisted hatching | .30 | <.001 | .13 | .07 | ||||
| Yes | 58 (28.4) | 8,306 (29.2) | 683 (45.5) | 798 (50.3) | ||||
| No | 42 (34.1) | 18,959 (42.6) | 272 (51.0) | 3,990 (57.2) | ||||
| No. of embryos transferredb | .07 | <.001 | .98 | .001 | ||||
| 1 | 24 (24.2) | 5,897 (34.3) | 375 (46.9) | 1,324 (51.9) | ||||
| ≥2 | 76 (33.3) | 21,368 (38.3) | 580 (47.0) | 3,464 (57.6) | ||||
| Embryo stageb | — | <.001 | — | <.001 | ||||
| Cleavage (2–3 d) | —f | 8,726 (27.1) | —e | 583 (43.2) | ||||
| Blastocyst (5–6 d) | —f | 18,132 (46.0) | —e | 4,112 (58.5) | ||||
| Other | —f | 374 (28.6) | —e | 83 (52.5) | ||||
Cycles started in 2013 where cryopreserved oocytes are thawed with the intent of fertilizing the oocytes and transferring the resulting embryos to the patient.
Missing <1% for prior pregnancies, prior births, prior ART cycles, ICSI; missing 1% for cryopreservation; missing 3% for embryo stage among fresh transfers; missing 9% for retrieval age among fresh donor retrievals; missing ≥20% for retrieval age, number of oocytes retrieved, and length of freeze among frozen autologous retrievals and retrieval age among frozen donor retrievals.
Percentages are among cycles transferring at least one embryo.
Suppressed for confidentiality. Either count was between 1 and 5 or cell contents allowed for the calculation of a count between 1 and 5.
Donor cycles could not be linked to a retrieval.
Autologous cycles could be linked to a retrieval, but embryo stage was only available for retrievals resulting in transfer (i.e. not banking cycles).
Crawford. Cryopreserved oocyte cycles. Fertil Steril 2016.