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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Fertil Steril. 2016 Nov 11;107(1):110–118. doi: 10.1016/j.fertnstert.2016.10.002

TABLE 3.

Outcomes of autologous and donor cycles started in 2013, comparing cryopreserved oocyte and fresh oocyte cycles.

Outcome Autologous cycles Donor cycles
Cryopreserved oocytea cycles (%) Fresh oocyte cycles (%) RRb 95% CI aRRb 95% CI Cryopreserved oocytea cycles (%) Fresh oocyte cycles (%) RRb 95% CI aRRb 95% CI
All cyclesc
 Cancellation before retrieval/thawd 9.5 9.6 0.99 0.67–1.46 0.93 0.65–1.34 3.9 4.4 0.89 0.60–1.31 0.89 0.60–1.31
 Cancellation before transfer 22.5 21.6 1.04 0.83–1.31 0.91 0.75–1.09 8.5 11.5 0.74f 0.57–0.96f 0.74f 0.57–0.96f
 Pregnancy 29.1 35.7 0.82f 0.69–0.97f 0.94 0.77–1.13 51.1 58.5 0.87f 0.81–0.95f 0.88f 0.81–0.95f
 Live birth 23.7 29.3 0.81f 0.67–0.97f 0.94 0.75–1.17 43.0 49.4 0.87f 0.79–0.95f 0.87f 0.80–0.95f
Transfers onlye
 Implantation  21.7 27.3 0.79f 0.65–0.97f 1.08 0.86–1.35 39.9 49.0 0.81f 0.73–0.91f 0.99 0.89–1.09
 Pregnancy 37.6 45.6 0.83f 0.70–0.98f 1.06 0.89–1.25 55.9 66.1 0.85f 0.79–0.91f 0.97 0.90–1.04
 Live birth 30.6 37.4 0.82f 0.69–0.98f 1.05 0.86–1.30 47.0 55.9 0.84f 0.78–0.91f 0.98 0.90–1.06
Pregnancies onlye
 Miscarriage 15.4 15.9 0.97 0.65–1.46 0.72 0.45–1.15 14.5 13.5 1.07 0.94–1.22 1.04 0.92–1.21
  1 embryo transferred — — — — — — 12.1 16.2 0.75f 0.58–0.95f 0.75f 0.58–0.97f
  ≥2 embryos transferred — — — — — — 15.9 12.4 1.29f 1.08–1.54f 1.28f 1.07–1.54f
 Live birth 81.3 82.0 0.99 0.91–1.08 0.98 0.88–1.09 84.1 84.7 0.99 0.97–1.02 0.98 0.96–1.01
  1 embryo transferred — — — — — — 86.4 81.9 1.06f 1.02–1.10f 1.05f 1.01–1.09f
  ≥2 embryos transferred — — — — — — 82.6 85.8 0.96f 0.93–1.00f 0.95f 0.92–0.99f
a

Cycles started in 2013 where cryopreserved oocytes are thawed with the intent of fertilizing the oocytes and transferring the resulting embryos to the patient.

b

Reference group = fresh oocyte.

c

Adjusted for significant risk factors from the set of all possible cycle-level risk factors. For autologous cycles, significant covariates included patient age, number of prior pregnancies, and diagnoses of diminished ovarian reserve, endometriosis, ovulatory dysfunction, male factor, and unexplained infertility (cancellation before retrieval/thaw); patient age, number of prior pregnancies, number of prior births, and diagnoses of diminished ovarian reserve, tubal factor, male factor, other and unexplained infertility (cancellation before transfer); and patient age, number of prior pregnancies, number of prior births, number of prior ART cycles and diagnoses of diminished ovarian reserve, ovulatory dysfunction, tubal factor, uterine factor, male factor, other and unexplained infertility (pregnancy and live birth). For donor cycles, significant covariates included none (cancellation before retrieval/thaw and cancellation before transfer); patient age and diagnoses of ovulatory dysfunction and tubal factor infertility (pregnancy); patient age, number of prior births and diagnoses of ovulatory dysfunction and tubal factor infertility (live birth).

d

Retrieval for fresh oocyte cycles and thaw for cryopreserved oocyte cycles.

e

Adjusted for significant risk factors from the set of all possible cycle-, retrieval- and transfer-level risk factors. For autologous transfers, significant covariates included: patient age, number of prior pregnancies, number of prior births, number of prior ART cycles, diagnoses of diminished ovarian reserve, ovulatory dysfunction, tubal factor, uterine factor, and male factor infertility, use of ICSI, number of embryos cryopreserved, use of assisted hatching, and the number of embryos transferred (implantation); patient age, number of prior pregnancies, number of prior births, number of prior ART cycles, diagnoses of diminished ovarian reserve, ovulatory dysfunction, tubal factor, uterine factor, and male factor infertility, use of ICSI, number of embryos cryopreserved, use of assisted hatching, and number of embryos transferred (pregnancy); patient age, number of prior births, number of prior ART cycles, diagnoses of diminished ovarian reserve, tubal factor, uterine factor, and male factor infertility, use of ICSI, number of embryos cryopreserved, use of assisted hatching, and number of embryos transferred (live birth). For donor transfers, significant covariates included: patient age, number of prior ART cycles, tubal factor infertility, use of ICSI, number of embryos cryopreserved, use of assisted hatching, and number of embryos transferred (implantation); patient age, number of prior ART cycles, diagnoses of ovulatory dysfunction and tubal factor infertility, number of embryos cryopreserved, use of assisted hatching, number of embryos transferred, and clinic size (pregnancy); patient age, number of prior births, number of prior ART cycles, diagnoses of ovulatory dysfunction and tubal factor infertility, number of embryos cryopreserved, use of assisted hatching, and number of embryos transferred (live birth). For autologous pregnancies, significant covariates included: patient age, number of prior pregnancies, number of prior births, diagnoses of ovulatory dysfunction, uterine factor, male factor and unexplained infertility, number of embryos cryopreserved, use of assisted hatching, number of embryos transferred and clinic size (miscarriage); patient age, number of prior pregnancies, number of prior births, diagnoses of ovulatory dysfunction, tubal factor and uterine factor infertility, number of embryos cryopreserved, use of assisted hatching, and number of embryos transferred (live birth). For donor pregnancies, significant covariates included: number of prior pregnancies, number of prior births, tubal factor infertility, and number of embryos transferred (miscarriage), number of prior pregnancies, number of prior births, tubal factor infertility, number of embryos transferred, and clinic size (live birth).

f

Statistically significant association.

Crawford. Cryopreserved oocyte cycles. Fertil Steril 2016.