Fig 7. CRP induces apoptosis and suppresses autophagy.

(A) Binding of Beclin 1 to Bcl-2 by co-IP in LC3 mice and PLC3 mice post-IRI. (B) Number of TUNEL positive cells in LC3 mice, PLC3 mice and PLC3 mice with rapamycin injection post-IRI. Data are expressed as means ± SD of 4 mice from each group and statistical significance was assessed by one-way ANOVA followed by Newman-Keuls test. *: P<0.05, **: P<0.01 between two groups. (C) Binding of Beclin 1 and Bcl-2 by co-IP in PLC3 mice post-IRI with or without rapamycin injection before surgery. KL: whole kidney lysates.