Table 2.

Treatment-related adverse events at least possibly related to orteronel.

Adverse Event	Grade 1 n (%)	Grade 2 n (%)	Grade 3 n (%)
Fatigue	1 (12%)
Nausea	3 (37%)	1 (12%)
Chills	1 (12%)
Hot Flashes	2 (25%)
Skin changes	1 (12%)
Headache		1 (12%)
Hirsuitism	1 (12%)
Bone Pain	2 (25%)	1 (12%)
Myalgia	2 (25%)
Hypertension			2 (25%)
Hypokalemia	2 (25%)
Hyperglycemia	1 (12%)
Hypoglycemia	1 (12%)
Hypocalcaemia	1 (12%)
Hypophosphatemia		1 (12%)
QT prolongation	1 (12%)
AST elevation	2 (25%)
Lymphopenia		1 (12%)
Creatinine elevation	1 (12%)