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. 2017 Sep 1;10:4329–4338. doi: 10.2147/OTT.S141345

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© 2017 Asari et al. This work is published and licensed by Dove Medical Press Limited

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Effect of SD1029 on POMC mRNA and adrenocorticotropic hormone (ACTH) levels in AtT20 cells.

Notes: Cell-culture treatments were conducted in triplicate, and the averages of three independent experiments are shown (the average of triplicates was considered as n=1, in this experiment n=3). One-way ANOVA was conducted, followed by Fisher’s protected least significant difference post hoc test to determine differences between treatment means (*P<0.05 compared with control [C]). (A) Time-dependent effect of SD1029 on POMC mRNA levels; cells were incubated with medium containing 10 µM SD1029. (B) Dose-dependent effects of SD1029 on POMC mRNA levels; cells were incubated for 24 hours with medium containing between 100 nM and 10 µM SD1029. (C) Dose-dependent effects of SD1029 on ACTH levels in AtT20 cells; cells were incubated for 24 hours with medium containing between 100 nM and 10 µM SD1029.