Table 3.
Subgroup | Studies | Pooled HR | 95% CI | P-value | Model | Heterogeneity I2 (%) | P-value |
---|---|---|---|---|---|---|---|
Ethnicity | |||||||
Asian | 14 | 1.54 | 1.25–1.89 | <0.0001 | Random | 82 | <0.00001 |
Caucasian | 4 | 2.04 | 1.08–3.86 | 0.03 | Random | 71 | 0.01 |
Cutoff of staining | |||||||
<50% | 10 | 1.52 | 1.09–2.12 | 0.01 | Random | 78 | <0.00001 |
≥50% | 7 | 1.78 | 1.40–2.27 | <0.0001 | Random | 72 | 0.002 |
Number of patients | |||||||
<100 | 6 | 1.64 | 1.49–1.81 | <0.00001 | Fixed | 0 | 0.48 |
≥100 | 12 | 1.51 | 1.15–1.97 | 0.003 | Random | 84 | <0.00001 |
Abbreviations: HR, hazard ratio; CI, confidence interval.