Table 1.

The properties of the TRPC family members

Category	Tissue distribution	Structure	Activation mechanism	Proposed regulation	Reference
TRPC1	Heart, Cartilage, Pituitary gland, Cerebellum, Caudate nucleus, Amygdala.	Six transmembrane spanning domains, TRP box in the C-terminus and three to four ankyrin-like repetitive sequences in the N-terminus	PKC-dependent phosphorylation	Store-operated, Store depletion	Riccio et al., 2002; Nilius and Voets, 2005; Minke, 2006; Xia et al., 2014
TRPC3	Pituitary gland, Cerebellum, Caudate nucleus, Putamen, Striatum.	Ibid ibidem	PKC-independent mechanism	DAG, Store-operated, Store depletion	Riccio et al., 2002; Welsh et al., 2002; Minke, 2006
TRPC4	Prostate, Bone. Parahippocampus.	Ibid ibidem	G-protein-coupled agonists	Store-operated, Store depletion?	Schaefer et al., 2000; Riccio et al., 2002; Plant and Schaefer, 2003
TRPC5	Cerebellum, Middle frontal gyrus, superior frontal gyrus	Ibid ibidem	G-protein-coupled agonists	Store-operated, Store depletion?	Schaefer et al., 2000; Riccio et al., 2002; Plant and Schaefer, 2003
TRPC6	Heart, Kidney, Adipose, Prostate, Cerebellum, Cingulate gyrus.	Ibid ibidem	PKC-independent mechanism	DAG, Receptor-operated	Riccio et al., 2002; Welsh et al., 2002; Winn et al., 2005; Xia et al., 2014
TRPC7	Pituitary gland, Kidney, Intestine, Prostate, Brain, Testis, Spleen, Cartilage.	Ibid ibidem	PKC-independent mechanism	DAG, Store depletion	Okada et al., 1999; Riccio et al., 2002
TRPC2	Only expressed in rodent,	Ibid ibidem	PLC-dependent mechanism	DAG, Store depletion?	Leypold et al., 2002; Stowers et al., 2002

“?” indicates that the proposed regulation is not completely confirmed.