Table 2.

TRPC channels may participate in most cardio/cerebro-vascular diseases

Disease	Related TRPCs	Cells	Reference
Hypertension	TRPC1,TRPC3,TRPC6	SMCs, Monocytes	Dietrich et al., 2006; Chen et al., 2010; Dietrich et al., 2010; Inoue et al., 2009; Fuchs et al., 2010; Eder and Molkentin, 2011; Gopal et al., 2015
Pulmonary hypertension	TRPC1,TRPC3,TRPC6	PASMCs	Liu et al., 2007a, 2009; Edwards et al., 2010; Iwasaki et al., 2011; Liu et al., 2012; Loga et al., 2013; Malczyk et al., 2013; Maier et al., 2015
Cardiac hypertrophy	TRPC1,TRPC3,TRPC6, TRPC7	Cardiomyocytes	Piper et al., 2004; Montell, 2005; Minke, 2006; Onohara et al., 2006; Nakashima and Kumagai, 2007; Ohba et al., 2007; Rosenbaum et al., 2015
Atherosclerosis	TRPC1,TRPC3,TRPC4, TRPC5,TRPC6	Platelets, VSMCs, Monocytes/Macrophages, Endothelial cells	Short et al., 1993; Satoh et al., 2007; Shan et al., 2008; Smedlund and Vazquez, 2008; Smedlund et al., 2010
Arrhythmia	TRPC3,TRPC6	Myocardial cells, Fibroblast	Wang et al., 2006; Takahashi et al., 2007; Thilo et al., 2009; Tauseef et al., 2016
Ischemia-reperfusion	TRPC3,TRPC6	Myocardial cells	Xu and Beech, 2001; Wu et al., 2010; Zhang et al., 2014