. 2017 Mar 10;25(5):471–481. doi: 10.4062/biomolther.2016.096

Table 3.

The essential information about inhibitors of TRPC channels or interdependent channels.

Inhibitor	Chemical structure	Targeting channels	Predicted effects	Action mechanism	Reference
SKF96365		TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPC7	Selectively decrease receptor-mediated calcium entry (RMCE) in human platelets, neutrophils and endothelial cells	Inhibit receptor-mediated Ca²⁺ entry and voltage-gated Ca²⁺ entry	Merritt et al., 1990; Farooqi et al., 2013
Pyrazole-3 (Pyr3)		TRPC3	Prevent stent-induced arterial remodeling and inhibit SMC proliferation	Inhibit TRPC3 by binding to the extracellular side of the receptor	Rowell et al., 2010; Christian and Maik, 2011; Koenig et al., 2013
SAR7334		TRPC3, TRPC6, TRPC7	Effect on acute hypoxic pulmonary vasoconstriction and systemic blood pressure	Inhibit TRPC3, TRPC6, TRPC7-mediated Ca²⁺ influx into cells	Maier et al., 2015
GsMTx-4	Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH2	Stretch-activated ion channels and NaV1.7 Na ⁺ channels and TRPC1, TRPC6	Potential therapeutic targets for cardiac arrhythmias	Inhibit Na⁺ voltage-gated channels and cation-selective mechanosensitive channels	Franz and Bode, 2003; Bowman et al.,2007; Rowell et al., 2010
BTP2		TRPCs and Store-operated Ca²⁺ influx and Ca²⁺ release-activat ed Ca²⁺ channels	Suppresses cytokine production (IL-2, IL-4, IL-5, IFN-γ, etc.) and proliferation in T cells in vitro	Inhibit anti-CD3 antibody-induced sustained Ca²⁺ influx	Ohga et al., 2008; Rowell et al., 2010