Table 1.

Histopathological findings and grading of the liver of males

Dose level (mg/kg/day)	0	0.5	5	50	250
No. of animals observed	5	5	5	5	5
Altered cell foci	+ (0/5)	+ (1/5)	+ (0/5)	+ (1/5)	+ (2/5)
	++ (0/5)	++ (1/5)	++ (2/5)	++ (2/5)	++ (1/5)
	+++ (0/5)	+++ (0/5)	+++ (0/5)	+++ (1/5)	+++ (2/5)
Bile duct hyperplasia	+ (0/5)	+ (3/5)	+ (1/5)	+ (1/5)	+ (0/5)
	++ (0/5)	++ (1/5)	++ (2/5)	++ (2/5)	++ (2/5)
	+++ (0/5)	+++ (1/5)	+++ (2/5)	+++ (2/5)	+++ (3/5)
Focal inflammation	+ (0/5)	+ (2/5)	+ (2/5)	+ (4/5)	+ (2/5)
	++ (0/5)	++ (0/5)	++ (3/5)	++ (0/5)	++ (2/5)
	+++ (0/5)	+++ (0/5)	+++ (0/5)	+++ (1/5)	+++ (1/5)

( ): Number of animals, Affected animals/Total examined animals.