Table 2.
Summary of common themes in all of the identified radiomic-pathway association modules. Columns 1–3 display the module name, the number of radiomic features (nr), and pathways (np), respectively. Columns 4–5 hold the radiomic and pathway themes present in each module.
| Module | nr | np | Radiomic | Pathway |
|---|---|---|---|---|
| M1 | 6 | 7 | Wavelet texture gray-level runs | Lipid and lipoprotein metabolism, Notch signaling, circadian clock |
| M2 | 58 | 5 | Wavelet intensity entropy; Laplace of Gaussian intensity standard deviation | Immune system, p53 |
| M3 | 4 | 17 | Wavelet minimum intensity | Neural system, axon guidance |
| M4 | 25 | 14 | Intensity variance and mean; wavelet minimum intensity min | Biological oxidations, signaling by insulin receptor, signaling by GPCR, neuronal system |
| M5 | 58 | 8 | Wavelet texture gray-level runs; wavelet intensity range and median; (wavelet) texture information correlation and cluster tendency | Axon guidance and synaptic transmission, lipoprotein metabolism, cell type determination |
| M6 | 64 | 7 | Laplace of Gaussian standard deviation; wavelet texture gray-level runs; wavelet texture cluster tendency | Circadian clock, signaling by Notch |
| M7 | 39 | 8 | Laplace of Gaussian intensity entropy; wavelet intensity variance; Laplace of Gaussian texture information correlation | Mitochondria, Pol III transcription |
| M8 | 20 | 17 | Laplace of Gaussian standard deviation | TCA cycle and electron transport, TGF-beta receptor signaling, response to stress, transcription regulation, protein synthesis, |
| M9 | 8 | 30 | Intensity variance; wavelet intensity variance | Immune system, p53, cell cycle regulation checkpoints, cell-cell interaction, circadian clock |
| M10 | 5 | 83 | Shape surface (SH); wavelet texture gray-level runs | Axon guidance, neuronal system, (innate) immune system, hemostasis, FGFR signaling, TGF-beta receptor signaling, Notch signaling, circadian clock |
| M11 | 17 | 66 | Wavelet intensity range; wavelet texture information correlation | Hemostasis, neural system |
| M12 | 32 | 27 | Wavelet texture entropy; intensity variance; wavelet texture cluster tendency | P53, immune system |
| M13 | 39 | 26 | Intensity entropy | Gene expression regulation, Pol II/III transcription |