Table 3.

Results of binding affinity assay of compounds 1–22 for human cannabinoid (subtypes CB1 and CB2) and opioid receptors (subtypes δ, κ, and μ)

Compounds	CB1 % Displacement	CB2 % Displacement	δ % Displacement	κ % Displacement	μ % Displacement
1	–	–	–	5.3	–
2	–	–	–	–	–
3	15.9	–	–	6.9	–
4	36.9	69.7	–	11.7	9.1
5	–	–	–	7.7	–
6	2.9	22.2	3.1	16.7	23
7	1.7	14.8	–	12.9	–
8	39.1	0.4	22.8	22.1	–
9	9.1	–	7.3	7.6	–
10	15.8	–	9.2	7.5	–
11	11.3	62.5	–	7	11.5
12	11.8	5.5	–	36.1	–
13	24.9	17.5	–	28.1	–
14	44.5	–	13.2	16.1	–
15	44.4	86.6	–	2.7	1.9
16	22.4	17.1	–	16.7	5.8
17	–	–	4.7	30.9	5.2
18	–	–	3.4	10.7	7.1
19	22.8	–	2.6	–	–
20	7	–	–	–	28.5
21	–	3.4	–	26.5	8.9
22	32.2	–	21.2	–	–
CP-55,940	91.49	103.34	–	–	–
Naloxone	–	–	99.11	101.43	101.92