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. Author manuscript; available in PMC: 2017 Sep 8.
Published in final edited form as: Arch Pharm Res. 2016 Jun 27;39(7):897–911. doi: 10.1007/s12272-016-0784-y

Table 5.

Molecular properties of the active compounds

Compounds Molecular weight Log S TPSA Log P(o/w) VSA
4 499 −10.46 35.53 8.41 523.7
11 515 −9.74 55.76 7.34 533.3
15 429 −10.53 34.14 7.17 500.4
CP-55,940 377 −6.67 60.69 6.34 461.2

Different molecular descriptors were calculated including their molecular weight, solubility, polar surface area, partition coefficient, and Van Der Waals surface area