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. 2017 Sep 8;12(9):e0183854. doi: 10.1371/journal.pone.0183854

Table 3. Functional enrichment of 45 differentially expressed genes (from Table 2) in brain tissue of Slc1a1-HET and WT mice.

GO- Biological Process Pathways    
Pathway ID Pathway Description Gene Count FDR Genes
GO:0050890 Cognition 7 0.00399 Arc, Chrm1, Grin2a, Rgs14, Slc17a7, Sorcs3, Tbr1
GO:0007611 Learning or memory 6 0.0187 Arc, Grin2a, Rgs14, Slc17a7, Sorcs3, Tbr1
GO:0007612 Learning 5 0.021 Arc, Grin2a, Rgs14, Sorcs3, Tbr1
GO:0044708 Single-organism behavior 7 0.0325 Arc, Grin2a, Rgs14, Slc17a7, Slitrk5, Sorcs3, Tbr1
GO- Cellular Component Pathways  
Pathway ID Pathway Description Gene Count FDR Genes
GO:0014069 Postsynaptic density 5 0.0216 Arc, Chrm1, Grin2a, Rgs14, Sorcs3
GO:0043197 Dendritic spine 4 0.0216 Arc, Grin2a, Nr1d1, Rgs14
GO:0030425 Dendrite 6 0.0364 Arc, Chrm1, Grin2a, Nr1d1, Prkca, Rgs14
GO:0043005 Neuron projection 8 0.0364 Arc, Ccsap, Chrm1, Grin2a, Nr1d1, Prkca, Rgs14, Slc17a7
GO:0097458 Neuron part 9 0.0364 Arc, Ccsap, Chrm1, Grin2a, Nr1d1, Prkca, Rgs14, Slc17a7, Sorcs3
KEGG Pathways  
Pathway ID Pathway Description Gene Count FDR Genes
4724 Glutamatergic synapse 4 0.0212 Grin2a, Prkca, Slc17a7, Slc1a1
5031 Amphetamine addiction 3 0.0362 Arc, Grin2a, Prkca