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. 2017 Sep 8;12(9):e0183854. doi: 10.1371/journal.pone.0183854

Table 5. Functional enrichment of 74 differentially expressed genes (from Table 4) in blood tissue of Slc1a1-HET and WT mice.

GO- Biological Process Pathways      
Pathway ID Pathway Description Gene Count FDR Genes
GO.0043922 Negative regulation by host of viral transcription 3 0.043 Ccl3, Ccl4, Jun
GO.0002376 Immune system process 14 0.047 Ccl3, Ccl4, Clnk, Fasl, Ifng, Irf7, Jun, Junb, Kit, Mylpf, Osm, Rhd, Tbx21, Tnk1
GO.0002763 Positive regulation of myeloid leukocyte differentiation 4 0.047 Ccl3, Fos, Ifng, Jun
GO.0006955 Immune response 10 0.047 Ccl3, Ccl4, Clnk, Fasl, Ifng, Irf7, Kit, Mylpf, Osm, Tnk1
GO.0050900 Leukocyte migration 5 0.047 Ccl3, Ccl4, Ifng, Kit, Tbx21
GO.0002891 Positive regulation of immunoglobulin mediated immune response 3 0.048 Fcer2a, Ifng, Tbx21
GO.0006925 Inflammatory cell apoptotic process 2 0.048 Fasl, Ifng
GO.0009314 Response to radiation 7 0.048 Cirbp, Dtl, Dusp1, Fos, Jun, Junb, Plk3
GO.0030595 Leukocyte chemotaxis 4 0.048 Ccl3, Ccl4, Ifng, Kit
GO.0032496 Response to lipopolysaccharide 6 0.048 Ccl3, Fasl, Fos, Ifng, Jun, Junb
GO.0034097 Response to cytokine 8 0.048 Darc, Fos, Ifng, Jun, Junb, Kit, Osm, Socs2
GO.0042493 Response to drug 7 0.048 Ccl3, Ccl4, Fos, Ifng, Jun, Junb, Prnp
GO.0045672 Positive regulation of osteoclast differentiation 3 0.048 Ccl3, Fos, Ifng
GO.0051591 Response to cAMP 4 0.048 Dusp1, Fos, Jun, Junb
GO.0070887 Cellular response to chemical stimulus 14 0.048 Ccl3, Darc, Dusp1, Ifng, Jun, Junb, Kit, Osm, Plk3, Ppp1r15a, Prnp, Slc16a1, Socs2, Tbx21
GO.1990441 Negative regulation of transcription from RNA polymerase II promoter in response to ER stress 2 0.048 Jun, Ppp1r15a
KEGG Pathways  
Pathway ID Pathway Description Gene Count FDR Genes
5132 Salmonella infection 6 2.00E-05 Ccl3, Ccl4, Fos, Ifng, Jun, Tjp1
4060 Cytokine-cytokine receptor interaction 7 0.001 Ccl3, Ccl4, Fasl, Ifng, Kit, Osm, Tnfrsf9
4620 Toll-like receptor signaling pathway 5 0.001 Ccl3, Ccl4, Fos, Irf7, Jun
5142 Chagas disease (American trypanosomiasis) 5 0.001 Ccl3, Fasl, Fos, Ifng, Jun
5323 Rheumatoid arthritis 4 0.004 Ccl3, Fos, Ifng, Jun
5168 Herpes simplex infection 5 0.009 Fasl, Fos, Ifng, Irf7, Jun
5144 Malaria 3 0.01 Darc, Gypa, Ifng
4380 Osteoclast differentiation 4 0.012 Fos, Ifng, Jun, Junb
5321 Inflammatory bowel disease (IBD) 3 0.017 Ifng, Jun, Tbx21
5161 Hepatitis B 4 0.018 Fasl, Fos, Irf7, Jun
5140 Leishmaniasis 3 0.019 Fos, Ifng, Jun
5164 Influenza A 4 0.028 Fasl, Ifng, Irf7, Jun