Table 6. Upstream regulator findings for differentially expressed genes in brain and blood.
| Brain | ||||
| Upstream Regulator | Molecule Type | Activation Z-Score | P-Value of Overlap | Target Molecules in Dataset |
| TGFB1 | Growth factor | 1.94 | 3.24E-02 | GRIN2A, JUNB, P4HA1, PPP1R3C, PRKCA, SLIT3, TNFAIP6 |
| Forskolin | Chemical toxicant | 1.92 | 3.52E-02 | ARC, JUNB, PPP1R3C, TNFAIP6 |
| Lipopolysaccharide (LPS) | Chemical drug | 1.68 | 1.14E-02 | ARC, EFNB2, FOXG1, JUNB, P4HA1, PRKCA, SCUBE1, TNFAIP6 |
| APP | Other | 1.52 | 2.23E-02 | ARC, GRIN2A, JUNB, NR1D1, PRKCA |
| Morphine | Chemical drug | 1.51 | 1.24E-04 | ARC, GRIN2A, JUNB, SLC1A1 |
| Tumor Necrosis Factor (TNF) | Cytokine | 1.4 | 8.44E-04 | ARC, EFNB2, JUNB, LAMA4, PPP1R3C, PRKCA, RGS14, SCUBE1, TNFAIP6, ZNF318 |
| Cocaine | Chemical drug | 1.22 | 3.13E-04 | ARC, EFNB2, JUNB, Zfp948 |
| CREB1 | Transcription regulator | 1.07 | 1.90E-02 | ARC, JUNB, SORCS3, Zfp948 |
| LY294002 | Kinase inhibitor | 1 | 1.42E-02 | ADIPOR2, EFNB2, JUNB, SLC1A1 |
| FGF2 | Growth factor | 0.96 | 4.42E-03 | ARC, EFNB2, GRIN2A, JUNB |
| IL1B | Cytokine | 0.65 | 5.16E-03 | ARC, DBP, JUNB, NR1D1, SCUBE1, TNFAIP6 |
| Phorbol Myristate Acetate (PMA) | Chemical drug | 0.61 | 3.41E-03 | DBP, EFNB2, GRIN2A, JUNB, PRKCA, SLITRK3, TNFAIP6 |
| IFNG | Cytokine | 0.58 | 5.32E-04 | ARC, DBP, EFNB2, JUNB, NR1D1, PRKCA, SCUBE1, SLC6A6, TNFAIP6 |
| Ca2+ | Chemical—endogenous | 0.28 | 1.39E-03 | ARC, DBP, JUNB, NR1D1 |
| L-dopa | Chemical—endogenous | 0.15 | 3.79E-02 | ARC, DBP, JUNB, RGS14 |
| NFkB (complex) | Complex | 0 | 2.63E-02 | DBP, JUNB, NR1D1, TNFAIP6 |
| Beta-estradiol | Chemical—endogenous | -0.21 | 1.40E-03 | ARC, CHRM1, EFNB2, FOXG1, GRIN2A, JUNB, LMO7, PPP1R3C, Srsf5, TNFAIP6 |
| PKC(s) | Group | -0.53 | 6.42E-04 | DBP, JUNB, NR1D1, PRKCA |
| ESR1 | Ligand-dependent nuclear receptor | -1.63 | 9.79E-03 | AP1M1, EFNB2, JUNB, NR1D1, PPP1R3C, SLC6A6, TNFAIP6 |
| 2-amino-5-phospho-novaleric acid | Chemical | -1.96 | 1.51E-04 | ARC, DACT2, JUNB, SLITRK3 |
| Blood | ||||
| Upstream Regulator | Molecule Type | Activation Z-Score | P-Value of Overlap | Target Molecules in Dataset |
| Lipopolysaccharide (LPS) | Chemical drug | 3.67 | 1.31E-09 | CCL3L3, CCL4, CENPI, DUSP1, Erdr1, FASLG, FOS, GFAP, IFNG, IRF7, JUN, JUNB, KIT, OSM, PLK3, PPP1R15A, RGS1, SOCS2, TBX21, TNFRSF9 |
| Tumor Necrosis Factor (TNF) | Cytokine | 3.54 | 2.77E-13 | CCL3L3, CCL4, CTSF, DUSP1, FADS1, FASLG, FCER2, FOS, GFAP, IFNG, IRF7, JUN, JUNB, KIT, OSM, PLK3, PPP1R15A, PRNP, RGS1, RRM2, SOCS2, TBX21, TJP1, TNFRSF9 |
| Phorbol Myristate Acetate (PMA) | Chemical drug | 3.38 | 4.50E-12 | CCL3L3, CCL4, DTL, DUSP1, FASLG, FOS, IFNG, IRF7, JUN, JUNB, KIT, MYLPF, OSM, PPP1R15A, PRNP, RGS1, SLC16A1, TBX21, TJP1 |
| Poly rI:rC-RNA | Biologic drug | 3.35 | 4.93E-10 | CCL3L3, CCL4, DUSP1, FASLG, FOS, IFNG, IRF7, JUN, JUNB, Oas1d, PPP1R15A, RGS1 |
| IL1B | Cytokine | 3.31 | 1.78E-10 | CCL4, CTSF, DUSP1, FASLG, FCER2, FOS, IFNG, IRF7, JUN, JUNB, OSM, PLK3, SOCS2, TBX21, TJP1, TNFRSF9 |
| IL2 | Cytokine | 3.24 | 8.18E-10 | CCL3L3, CCL4, CDC6, FASLG, FOS, GFAP, IFNG, JUN, KIT, OSM, SOCS2, TBX21, TNFRSF9 |
| IFNG | Cytokine | 3.2 | 9.52E-10 | CCL3L3, CCL4, CIRBP, DUSP1, FASLG, FCER2, FOS, GFAP, IFNG, IRF7, JUN, JUNB, OSM, PRNP, SOCS2, TBX21, TJP1, TMOD1 |
| NFkB (complex) | Cytokine | 3.2 | 2.11E-09 | CCL3L3, CCL4, FASLG, FCER2, FOS, GFAP, IFNG, IRF7, JUN, JUNB, KIT, PLK3, TNFRSF9 |
| CSF2 | Cytokine | 2.95 | 9.21E-10 | CCL3L3, CCL4, FOS, IFNG, OSM, PPP1R15A, PRNP, RRM2, SGO1, SKA1, SOCS2, TNFRSF9 |
| CD3 | Complex | -2.87 | 3.54E-06 | CCL3L3,CCL4,FASLG,FOS,IFNG,JUN,JUNB,SOCS2,TBX21,TNFRSF9 |
| IKBKB | Kinase | 2.8 | 7.31E-10 | CCL3L3, CCL4, CDC6, CTSF, FASLG, FOS, IFNG, JUNB, SOCS2, TNFRSF9 |
| RELA | Transcription regulator | 2.78 | 3.77E-07 | DUSP1, FASLG, FOS, IFNG, IRF7, JUN, JUNB, KIT, PLK3 |
| P38 MAPK | Group | 2.76 | 1.00E-09 | CCL3L3, DUSP1, FASLG, FCER2, FOS, IFNG, IRF7, JUN, JUNB, MYLPF, TBX21 |
| APP | Other | 2.76 | 1.09E-06 | CCL3L3, CCL4, FASLG, FOS, GFAP, IFNG, IRF7, JUN, JUNB, OSM, PRNP, TJP1 |
| TCR | Complex | 2.75 | 3.06E-09 | CCL3L3, CCL4, FASLG, FOS, IFNG, IRF7, JUN, JUNB, SOCS2, TBX21 |
| IL1 | Group | 2.71 | 1.69E-06 | CCL4, DUSP1, FASLG, FOS, GFAP, IFNG, JUN, KIT |
| CD40 | Transmembrane receptor | 2.7 | 2.38E-09 | CCL4, DUSP1, FASLG, FCER2, FOS, IFNG, JUN, TBX21, TNFRSF9 |
| IL21 | Cytokine | 2.62 | 2.37E-07 | CCL3L3, CCL4, FASLG, IFNG, IRF7, SOCS2, TBX21 |
| MAP2K1 | Kinase | 2.62 | 2.47E-07 | CCL3L3, CCL4, DUSP1, FASLG, FOS, JUN, OSM |
Entries in bold are common between brain and blood.