Table 7. Results of cytokine profiling assay in Slc1a1-HET vs. WT mouse brains.
| IL-4 | ||||||||
| Mean Square | F-Value | P-Value | Power | Scheffé's post hoc test | ||||
| Sex | 6.88E-05 | 9.341 | 0.0109 | 0.804 | Mean Diff. | Crit. Diff. | P-Value | |
| Genotype | 1.26E-04 | 17.129 | 0.0016 | 0.973 | F, M | 0.00405 | 0.00309 | 0.0149 |
| Sex * Genotype | 1.66E-05 | 2.247 | 0.162 | 0.266 | HET, WT | 0.00569 | 0.00309 | 0.0019 |
| IL-13 | ||||||||
| Mean Square | F-Value | P-Value | Power | Scheffé post hoc test | ||||
| Sex | 1.62E-07 | 0.73708 | 0.4089 | 0.11917 | Mean Diff. | Crit. Diff. | P-Value | |
| Genotype | 4.72E-06 | 21.53244 | 0.0007 | 0.99249 | F, M | 0.00011 | 0.00053 | 0.6724 |
| Sex * Genotype | 3.88E-07 | 1.76939 | 0.2104 | 0.21916 | HET, WT | 0.00109 | 0.00053 | 0.0009 |
| IL-5 | ||||||||
| Mean Square | F-Value | P-Value | Power | Scheffé post hoc test | ||||
| Sex | 4.43E-06 | 10.99198 | 0.0069 | 0.86694 | Mean Diff. | Crit. Diff. | P-Value | |
| Genotype | 0.00001 | 36.50142 | < .0001 | 0.99994 | F, M | 0.00093 | 0.00072 | 0.0165 |
| Sex * Genotype | 4.28E-07 | 1.06073 | 0.3252 | 0.15001 | HET, WT | 0.00189 | 0.00072 | 0.0001 |
| IL-17A | ||||||||
| Mean Square | F-Value | P-Value | Power | Scheffé post hoc test | ||||
| Sex | 1.00E-05 | 4.78509 | 0.0512 | 0.50654 | Mean Diff. | Crit. Diff. | P-Value | |
| Genotype | 0.00001 | 9.44245 | 0.0106 | 0.80873 | F, M | 0.00126 | 0.00137 | 0.0667 |
| Sex * Genotype | 8.58E-07 | 0.59603 | 0.4564 | 0.10589 | HET, WT | 0.00186 | 0.00137 | 0.0123 |
| IP-10/ CXCL10 | ||||||||
| Mean Square | F-Value | P-Value | Power | Scheffé post hoc test | ||||
| Sex | 2.00E-05 | 7.11 | 0.0219 | 0.68314 | Mean Diff. | Crit. Diff. | P-Value | |
| Genotype | 0.00003 | 12.74488 | 0.0044 | 0.91371 | F, M | 0.00191 | 0.00183 | 0.0417 |
| Sex * Genotype | 0.00001 | 2.80018 | 0.1224 | 0.32112 | HET, WT | 0.00272 | 0.00183 | 0.0074 |
| RANTES/ CCL5 | ||||||||
| Mean Square | F-Value | P-Value | Power | Scheffé post hoc test | ||||
| Sex | 1.55E-07 | 7.60029 | 0.0187 | 0.71373 | Mean Diff. | Crit. Diff. | P-Value | |
| Genotype | 1.81E-07 | 8.87796 | 0.0125 | 0.78282 | F, M | 0.00019 | 0.00016 | 0.0281 |
| Sex * Genotype | 3.78E-09 | 0.18528 | 0.6752 | 0.06753 | HET, WT | 0.0002 | 0.00016 | 0.0183 |
Two way (Sex x Genotype) ANOVA, followed by Scheffé post hoc test. Only cytokines with significantly different concentrations that also survived FDR correction of the significant main effect of Genotype at q < 0.25 are displayed. Note that Scheffé post hoc tests confirmed the differences between Het and WT groups for all 6 of these cytokines.