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. 2017 Sep 8;12(9):e0184577. doi: 10.1371/journal.pone.0184577

Table 1. Characteristics of the included studies in the systematic review.

Study (year) Design Species Outcome measurement Duration of treatment Sample size Study arms
Prediabetes
Akhiruddin (2013) Single-binded cross-over Hylocereus polyrhizus FPG 4 weeks 36 Mainly divided into PT and PC groups
- PT group (n = 18) was subdivided into PT3, PT4, PT5 (n = 6/group)
- PC group (n = 18) was subdivided into PC3, PC4, PC5 (n = 6/group)
Type 2 Diabetes
Hadi (2012) Non-blinded, Parallel Hylocereus polyrhizus FPG 4 weeks 28 (7:7:7:7) Group 1: 400 g red dragon fruit/day
Group 2: 600 g red dragon fruit/day
Group 3: No treatment
Group 4: Healthy subjects, no treatment
Hapsari
(2015)
Non-blinded, Parallel Hylocereus costaricensis FPG 15 days 30 (15:15) Group 1: 180 g red dragon fruit/day
Group 2: No treatment
Wiardani et al. (2014) Non-blinded, Parallel Hylocereus polyrhizus 2HPP 10 days 51 (17:17:17) Group 1: 100 g red dragon fruit juice/day
Group 2: 200 g red dragon fruit juice/day
Group 3: No treatment

Abbreviation: BMI = Body mass index, DBP = Diastolic blood pressure, FPG = Fasting plasma glucose, PT = Prediabetic treatment, PC = Prediabetic control, PT3 = 3 sachets or 60 g of red pitaya powder (RPP) drink/day, PT4 = 4 sachets or 80 g of RPP drink/day, PT5 = 5 sachets or 100 g of RPP drink/day, SBP = Systolic blood pressure, 2HPP = 2 hours post-prandial glucose