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. 2017 Sep 8;12(9):e0184533. doi: 10.1371/journal.pone.0184533

Fig 2. Maximum likelihood (ML) phylogenetic tree of human parechoviruses (HPeV) detected in Hong Kong.

Fig 2

Maximum likelihood tree constructed using RAxML MPI v8.2.8, based on the global nucleotide sequence alignment of the VP1 gene of HPeV isolates collected in this study, the represented complete genomes of HPeV1-8, and the VP1 gene of HPeV9-16. Numbers beside of branch nodes indicate bootstrap supports by RAxML; an asterisk (*) indicates 100% support while the index less than 50% was not shown in the tree. The Hong Kong isolates indicated in red were assigned to specific type based on the tree topology. The bar scale at the bottom of the tree indicates percent variation per unit length. The VP1 gene nucleotide sequences obtained in this study were submitted to NCBI/GenBank database, with accession numbers of MF435179—MF435277. “16V0080862” and “15V0315795” were the HPeV3 strains detected in this study. “15V0315795” close to the Yamagata 2011 lineage (AB759199) was from a 6-day neonate with sepsis-like illness, while the “16V0080862” close to the Netherlands 2006 lineage (GQ183029) was from a 7-month girl with acute gastroenteritis. Both children were not coinfected with other pathogens.