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. 2017 Sep 8;12(9):e0184619. doi: 10.1371/journal.pone.0184619

Fig 4. mAagTg CGN sensitivity to MMS is not dependent on NAD+, pyruvate, caspases, Rip1K, calcium fluxes, or MPT.

Fig 4

(A) NAD+ pre-treatment did not rescue mAagTg neuron sensitivity to MMS. Errors bars denote standard deviation from the mean. mAagTg n = 3. (B) Pyruvate did not rescue mAagTg neuron sensitivity to MMS. Errors bars denote standard deviation from the mean. mAagTg n = 1. *** p<0.001 using Student’s standard two-tailed T-test comparing MMS and MMS + Veliparib. (C) Primary mAagTg CGN sensitivity to MMS is not dependent on caspase activation, Rip1 kinase activity, calcium fluxes, or mitochondrial permeability transition (MPT). Inhibitors used include zVad-fmk (zVad), n = 6, Necrostatin-1 (Nec-1), n = 3, BAPTA-AM, n = 3, and cyclosporin A (CsA), n = 3. Errors bars denote standard error from the mean. *** p<0.001 using Student’s standard two-tailed T-test comparing MMS to MMS+Veliparib.