Figure 2.

Intolerance to Missense Variation

Violin plots show the distribution of the gene-based $d_N/d_S$ (y axis) per gene set (x axis). The median $d_N/d_S$ is indicated by a red horizontal line. The NHI genes are more intolerant to missense variation than HI genes (HI genes median: 0.460; NHI genes median: 0.428; p = 2.24e-03). In addition, the identified genes with clustering mutations are more intolerant to missense variation than HI genes (genes with clustering mutations median: 0.352; p = 8.45e-03).