Table 2.

Gene Function for Candidate Genes with Clustered Mutations

Gene Name	Summary of Gene Function	Interactions
ACTL6B	Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth.	Complex formation with ACTB, ARID1A, SMARCA2, SMARCA4, SMARCE1, SMARCC1, SMARCC2, SMARCD2, SMARCB1
GABBR2	Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory.	Heterodimerization is required for the formation of a functional GABA-B receptor.
PACS2	Multifunctional sorting protein, controling endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis.	N/A

Third column indicates whether the encoded protein has physical interactions with other proteins. See Table S9 for extended information.