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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Allergy. 2017 Mar 31;72(10):1521–1531. doi: 10.1111/all.13158

Figure 6.

Figure 6

A Nrf2 activator inhibits airway inflammation and pathology in mice exposed repeatedly to Alternaria extract. A, Schematic diagram. Naïve BALB/c mice were pretreated daily with 50 μg CDDO-Me i.p. for 3 days and exposed i.n. to Alternaria extract (10 μg) 3 times/week for 2 weeks. Daily CDDO-Me treatment was continued throughout the experiment. Samples were collected 24 hours after the last Alternaria exposure. B, BAL fluids were analyzed by differential cell counts (left panel); cytokine levels in lung lysates (middle panel) and total IgE in sera (right panel) were analyzed by ELISA. Data are presented as mean±SEM from a pool of two experiments (n=7 or 10 mice in each group). *p<0.05 and **p<0.01 between groups indicated by horizontal lines. C, Lung specimens were analyzed by H&E and PAS staining. D, PAS-positive areas were quantitated by image analysis as described in the Materials and Methods. Data are presented as mean±SEM (n=3 mice in each group). *p<0.05 between groups indicated by horizontal lines.