. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: J Clin Pharmacol. 2017 Jun 1;57(10):1295–1304. doi: 10.1002/jcph.936

Table 5.

Comparison of changes in LPV exposure with hepatic impairment

	Observed^†	Predicted^†

Parameter	Mild to moderate HI	Child-Pugh A	Child Pugh B
AUC_SS	+30%	+60%	+143%
Cmax	+20%	+49%	+118%

Abbreviations: AUCss= area under the plasma concentration-time curve (steady state), Cmax=maximum plasma concentration, HI=hepatic impairment, LPV=lopinavir

^†

Predicted changes in lopinavir exposure were derived from arithmetic means, the type of means for the observed changes in lopinavir exposure is not specified in the lopinavir/ritonavir U.S. prescribing information.