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. 2017 Sep 8;7:11010. doi: 10.1038/s41598-017-11518-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PA induces a transient increase of interleukin-22 in the lungs. (a) IL-22 mRNA expression levels in total lungs at different time points of infection. Data are representative of two independent experiments (n = 3 per group). (b) IL-22 levels by ELISA in lung homogenates of mice infected at different time points. Boxes represent median (interquartile range). Data are representative of two independent experiments (n = 6 per infected group. n = 3 for the sham group). (c) IL-22 IHC of lung section from sham (panel 1) and infected mice at 6 (panel 2), 24 (panel 3) and 48hrs (panel 4). Data are representative of two independent experiments (n = 3 per group). Magnification: × 100. Bar = 100 μm. (d) Quantification of IL-22 positive pixels surface area by SIOX analysis of the slides presented in (c). Data are representative of two independent experiments (3 mice per group; four fields per slide). *p < 0.05, **p < 0.01, and n.s.: not significant compared with the sham group.