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. 2017 Sep 8;7:11037. doi: 10.1038/s41598-017-11444-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Variation of hypoxic proportions with tumor vascularity for (a) poor blood oxygenation (p ₀ = 20 mmHg and ND = 80 µm), (b) moderate blood oxygenation (p ₀ = 40 mmHg and ND = 180 µm) and (c) high blood oxygenation (p ₀ = 100 mmHg and ND = 300 µm).