Table 1.

Tumor growth model input parameters and values for HNSCC.

Input parameter	Values	Type	References
Cell (and blood vessel) diameter	14–20 µm	Distribution	11, 36, 37
RVV	2–10%	Single value	11, 12
Oxygen tension	$p(r)=p_0\frac{N{D}^2}{{R_0}^2}\left(2\ln \left(\frac{ND}{r}\right)-1+\frac{r^2}{N{D}^2}\right)$ where${R_0}^2=N{D}^2\left(2\ln \left(\frac{ND}{a}\right)-1\right)$, a = 10 µm	Distribution	38, 39
p 0	20–100 mmHg	Single value	11, 13
ND	80–300 µm	Single value	14, 15
CCT under normoxia	33 ± 5.9 h (Gaussian)	Distribution	40, 41
CCT adjustment factor with hypoxia	$y({\mathrm{pO}}_2)=1+1.8e^{-0.2{\mathrm{pO}}_2}$	Distribution	40, 42, 43
Hypoxia-induced quiescence	pO2 < 1 mmHg	Single value	44–46
Necrotic cell resorption time	3–6 days depending on local necrotic volume	Distribution	47, 48
CSC symmetric division probability	~2% pre-treatment, possibly >50% during accelerated repopulation	Single value	6–8, 30, 40
Differentiated cell loss frequency	80%	Single value	40, 41