Table 3.
Effect of treatment in | Total relaxation | PGs (sensitive to INDO) | NO (sensitive to LNMMA) | EDHF (INDO + LNMMA resistant) |
---|---|---|---|---|
SHR | ||||
vildagliptin | ↑↑ | ↑↑ | ≈ | ≈↑ |
metformin | ↑↑ | ≈↓ | ↑↑ | ↑↑ |
STZ-SHR | ||||
vildagliptin | ≈ | ≈↓ | ≈↓ | ↑↑ |
metformin | ↑↑ | ≈ | ≈ | ↑↑ |
Symbols indicate directional changes induced by treatments compared to untreated SHR and untreated STZ-SHR. Double symbols ↓↓ and ↑↑ indicate a significant decrease and increase, respectively.