Table 3.

Summary of directional changes in endothelial mediators in acetylcholine-induced relaxation in SHR aorta: effect of treatments.

Effect of treatment in	Total relaxation	PGs (sensitive to INDO)	NO (sensitive to LNMMA)	EDHF (INDO + LNMMA resistant)
SHR
vildagliptin	↑↑	↑↑	≈	≈↑
metformin	↑↑	≈↓	↑↑	↑↑
STZ-SHR
vildagliptin	≈	≈↓	≈↓	↑↑
metformin	↑↑	≈	≈	↑↑

Symbols indicate directional changes induced by treatments compared to untreated SHR and untreated STZ-SHR. Double symbols ↓↓ and ↑↑ indicate a significant decrease and increase, respectively.