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. 2017 Sep 8;7:10975. doi: 10.1038/s41598-017-11430-7

Table 3.

Summary of directional changes in endothelial mediators in acetylcholine-induced relaxation in SHR aorta: effect of treatments.

Effect of treatment in Total relaxation PGs (sensitive to INDO) NO (sensitive to LNMMA) EDHF (INDO + LNMMA resistant)
SHR
  vildagliptin ↑↑ ↑↑ ≈↑
  metformin ↑↑ ≈↓ ↑↑ ↑↑
STZ-SHR
  vildagliptin ≈↓ ≈↓ ↑↑
  metformin ↑↑ ↑↑

Symbols indicate directional changes induced by treatments compared to untreated SHR and untreated STZ-SHR. Double symbols ↓↓ and ↑↑ indicate a significant decrease and increase, respectively.