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. 2001 Sep 15;29(18):3892–3899. doi: 10.1093/nar/29.18.3892

Figure 7.

Figure 7

Hypothetical changes in RPA interface with the primed template during RDP growth. (A) Presumptive switch of individual SSB motifs of RPA from template binding to potential interaction with the primer end during elongation of the DNA moiety of an RDP and contraction of the gap downstream. (B) The correlation of the Rpa2 → Rpa1 switch in crosslinking preference upon RDP maturation in situ (18 and this work) with that due to diminution of the synthetic template overhang or gap of in vitro reconstituted complexes (21,22) suggests that the ssDNA gap 3′ to the mature RDP is <20 nt. pppRRRRRRRRRR, RNA primer; DDDDDDDD . . . DDD, DNA strand. A–D indicate respective SSB motifs of RPA (24,35).